You may have seen the other reviews that tell you to NOT watch this movie.
They are correct.
Don't be cocky and think the "not worth your time" reviews are a hoax, that you LOVE terrible movies and that this will just be added to the list—don't be like me.
Don't think your love of B-Movie classics and Cronenburg-esque body horror will translate here. It is too high budget for that. The comedy lands flat. The body horror isn't even laughable or cringeworthy. The main character is so extremely unlikeable that you are pleased by his fate. He is only ever shown as a one-sided, totally flat, pretentious megalomaniac with a false sense of power/scope who belittles everyone in his life. 100% sure everyone who "cares" about him in this movie is better off without him. By the time Johnny Depp comes in with, possibly, the worst bit he's ever been delegated to, your mouth will already be agape in "WTF"? But, again, not even in a good way.
The plot holds promise, but could have been executed much more successfully with less budget, some actual creativity and willingness to get truly gruesome and weird (which it never quite manages), and better (or worse!) writing.
They should have given this script to Troma, they at least know how to handle these concepts.
Do yourself a favor—treat yourself to watching "In the Heart of the Sea" and then pick your favorite Cronenberg for some body horror, picture them together, and call it a night. This is not worth your time.